According to the historian Tyrannius Rufinus, he was converted to Christianity with his brother Ezana by the missionary Frumentius. With his brother, he resisted the attempts of the Christian Roman emperor Constantius II to relieve Frumentius of his post as bishop and replace him with an Arian (which was a different sect of Christianity).
Saizana was sent by King Ezana with his other brother Hadefa (alternatively spelled Adiphan, Adefa) to quell an uprising by the Beja. The two brothers were victorious, and six Beja tribes (4400 people) were relocated to a province called Matlia, which is believed to have been situated similarly to the modern province of Begemder in Ethiopia.
- Holweck, F. G., A Biographical Dictionary of the Saints. St. Louis, MO: B. Herder Book Co. 1924.
- E. Bernard, A.J. Drewes, and R. Schneider, Recueil des inscriptions de l'Éthiopie des périodes pré-axoumite et axoumite. Tome I: Les inscriptions. Paris: Diffusion de Boccard, 1991, p. 247.
- Stuart Munro-Hay. Aksum: An African Civilization of Late Antiquity. Edinburgh: University Press. 1991.